You might need a lessen dose of modafinil If you're 65 or more mature. Talk with your healthcare company if you are With this age team.

cyclophosphamide will enhance the amount or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.

de Saint Hilaire et al (2001) calculated arousal with EEG and local brain monoaminergic degrees working with microdialysis within the prefrontal cortex and also the ventromedial preoptic spot of your hypothalamus in rats given modafinil.

modafinil will improve the level or influence of diazepam buccal by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Powerful or moderate CYP2C19 inhibitors might reduce fee of diazepam elimination, thus escalating adverse reactions to diazepam.

Obstructive snooze apnea, a dysfunction that takes place when your respiratory stops and commences Whilst you snooze simply because your airway will get blocked

It is far from apparent exactly how modafinil works to further improve sleep cycles to help with obstructive snooze apnea, narcolepsy, or change function ailment. It may well contain mimicking substances in your brain that act like adrenaline or increasing dopamine (another chemical in your Mind) exercise.

Avoid or substitute A different drug for these drugs when feasible. Evaluate for loss of therapeutic effect if medication needs to be coadministered. Alter dose according to prescribing information and facts if wanted.

modafinil will minimize the extent or result of fruquintinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration with reasonable CYP3A4 inducers is unavoidable, continue to administer fruquintinib at advised dosage.

nelfinavir will enhance the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. website Use Caution/Keep track of.

Modafinil is known to obtain considerably less or no adverse effects than These located in traditional psychostimulants which include amphetamine, methylphenidate or copyright. It can be applied as an anti-psychotic or anti-tiredness agent.

Keep track of Intently (1)voriconazole will raise the degree or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

tazemetostat will lessen the level or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

Stay clear of coadministration of sensitive CYP3A4 substrates with ivosidenib or substitute with different therapies. If coadministration is unavoidable, observe patients for loss of therapeutic impact of these medications.

modafinil will raise the degree or result of diazepam intranasal by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Watch. Solid or average CYP2C19 inhibitors may perhaps minimize rate of diazepam elimination, thus increasing adverse reactions to diazepam.